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Dr. Mohammad Derbeih
Licensed Physician
الأسئلة المجابة 23118 | نسبة الرضا 98.9%
Doctor
About research for new antidepressant drugs...
About research for new antidepressant drugs ,mechanism ,pathophysiology,c/p picture for explain it, toxicisty of this drugs,
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إجابة الخبير: Dr. Mohammad Derbeih
Dr. Mohammad Derbeih
Licensed Physician
الأسئلة المجابة 23118 | نسبة الرضا 98.9%
Dear Customer
Welcome, and thank you for trusting us
Regarding your question
What is the new antidepressants ?
the newer antidepressants is the serotonin selective reuptake inhibitors SSRI's
What is SSRI's ?
SSRIs are commonly considered first-line treatment for depression
likely through increasing serotonergic activity
usually takes 3-8 weeks for therapeutic effects to occur
Names of SSRI's drugs
citalopram
Escitalopram
fluoxetine
fluvoxamine
paroxetine
sertraline
Mechanism of action of SSRI's
likely through decreasing the serotonin reuptake pump in presynaptic neurons
this in turn increases synaptic serotonin availability and serotonin receptor occupancy in postsynaptic neurons
serotonin reuptake receptor selectivity → relatively benign side-effects
cytochrome P450 inhibitor
citalopram and Escitalopram are the SSRI of choice if you're concerned about drug-to-drug interactions
Clinical use of SSRI's
major depressive disorder (MDD, first-line treatment)
obsessive-compulsive disorder
post traumatic stress disorder
panic disorder
generalized anxiety disorder
bulimia nervosa
binge eating disorder
social phobias
hoarding disorder
Toxicity of SSRI's
much milder than other depression therapies
weight gain
can cause QTc prolongation
anxiety, agitation, and insomnia
GI distress
sexual dysfunction
serotonin syndrome
anxiety, restlessness, disorientation, autonomic manifestations
(i.e., diaphoresis, hyperthermia, hypertension), and neuromuscular hyperactivity (i.e., myoclonus, hyperreflexia, muscle rigidity, tremor)
SSRI discontinuation syndrome
with abrupt discontinuation of the medication
fluoxetine is less likely to cause symptoms post abrupt discontinuation
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إسأل Licensed Physician
Dr. Mohammad Derbeih
Licensed Physician
الأسئلة المجابة 23118 | نسبة الرضا 98.9%
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